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Gefitinib hydrochloride
CAS No. 184475-55-6
Gefitinib hydrochloride ( ZD-1839 hydrochloride )
Catalog No. M12849 CAS No. 184475-55-6
A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGefitinib hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM.
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DescriptionA potent, selective, orally active EGFR inhibitor with IC50 of 23 nM; inhibits EGF-stimulated proliferation of KB cells with IC50 of 80 nM; blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50 of 0.2-0.4 uM; significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth; has been used to treat advanced (or recurrent) non-small cell lung cancer.Lung Cancer Approved
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SynonymsZD-1839 hydrochloride
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number184475-55-6
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Formula Weight483.36
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Molecular FormulaC22H25Cl2FN4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 0.227 mg/mL; H2O:< 4.8 mg/mL
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SMILESCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl
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Chemical Name4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barker AJ, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1911-4.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
2. Sirotnak FM, et al. Clin Cancer Res. 2000 Dec;6(12):4885-92.
3. Moasser MM, et al. Cancer Res. 2001 Oct 1;61(19):7184-8.
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